cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

Nature. 1987 Nov;330(6144):132-7. doi: 10.1038/330132a0.


Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Apolipoproteins A / genetics*
  • Base Sequence
  • Biological Evolution*
  • DNA / isolation & purification*
  • Humans
  • Molecular Sequence Data
  • Plasminogen / genetics*
  • Protein Conformation
  • Sequence Homology, Nucleic Acid


  • Apolipoproteins A
  • Plasminogen
  • DNA

Associated data

  • GENBANK/M17399
  • GENBANK/X06290
  • GENBANK/X06696