The structure of an oligo(dA).oligo(dT) tract and its biological implications

Nature. 1987 Nov 19-25;330(6145):221-6. doi: 10.1038/330221a0.

Abstract

Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Composition
  • Base Sequence
  • Crystallization
  • DNA
  • Hydrogen Bonding
  • Models, Molecular
  • Nucleic Acid Conformation
  • Oligodeoxyribonucleotides
  • Poly dA-dT*
  • Polydeoxyribonucleotides*
  • X-Ray Diffraction

Substances

  • Oligodeoxyribonucleotides
  • Polydeoxyribonucleotides
  • oligo (dT)
  • oligodeoxyadenylic acid
  • Poly dA-dT
  • DNA