A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea

Medicine (Baltimore). 2023 Jan 27;102(4):e32704. doi: 10.1097/MD.0000000000032704.


Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can cause serious infection. We aimed to analyze the prevalence and susceptibility rates to trimethoprim/sulfamethoxazole of S. maltophilia. We conducted a retrospective study of S. maltophilia isolates from a university hospital from 2001 to 2020. Clinical information, the numbers of isolates and susceptibility rates were analyzed by year. Susceptibility rates and changes in respiratory and non-respiratory samples were compared. 1805 S. maltophilia isolates were identified, of which 81.4% (1469/1805) were from respiratory samples. There was a male predominance and 52% of the isolates were from general wards. The average susceptibility rate was 87.7% and there was no significant annual trend (P = .519). The susceptibility rate was 88.7% in respiratory samples and 84.1% in non-respiratory samples (P = .018). Susceptibility analyses using clinical data over long periods can guide the choice of antimicrobials especially for pathogen whose treatment options are limited.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Female
  • Gram-Negative Bacterial Infections* / drug therapy
  • Gram-Negative Bacterial Infections* / epidemiology
  • Hospitals, University
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Prevalence
  • Republic of Korea / epidemiology
  • Retrospective Studies
  • Secondary Care
  • Stenotrophomonas maltophilia* / drug effects
  • Trimethoprim, Sulfamethoxazole Drug Combination* / pharmacology
  • Trimethoprim, Sulfamethoxazole Drug Combination* / therapeutic use


  • Anti-Bacterial Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination