BNT162b2 and mRNA-1273 Vaccine Effectiveness against SARS-CoV-2 and Variants in the Urban Underserved Population

R I Med J (2013). 2023 Feb 1;106(1):26-28.


The real world COVID-19 vaccine effectiveness among the urban underserved Hispanic/Latino populations is unknown. We evaluated the mRNA vaccine effectiveness in preventing SARS-CoV-2 infections at a major federally qualified health center in Providence, Rhode Island, and a total of 38,602 patients were included. Time period was used as the SARS-CoV-2 variant proxy. Compared to the unvaccinated group, the adjusted vaccine effectiveness for 2 doses of BNT162b2 and mRNA-1273 were 94.6% and 97.5% respectively against the alpha variant/wild type, which dropped to 64.8% and 65.0% respectively against the delta variant and 31.6% and 25.6% respectively against the omicron variant. However, once received the booster dose (3rd dose) of BNT162b2 and mRNA-1273, the vaccine effectiveness against the omicron variant improved to 79.9% and 71.2% respectively. Improving the COVID-19 vaccine education and encouraging to receive a booster dose may help further reduce the burden of SARS-CoV-2 infection in this population.

Keywords: COVID-19; Hispanic/Latino; underserved; vaccine effectiveness; variants.

MeSH terms

  • 2019-nCoV Vaccine mRNA-1273
  • BNT162 Vaccine*
  • COVID-19 Vaccines
  • COVID-19* / epidemiology
  • COVID-19* / prevention & control
  • Humans
  • SARS-CoV-2 / genetics
  • Vaccine Efficacy
  • Vulnerable Populations


  • BNT162 Vaccine
  • 2019-nCoV Vaccine mRNA-1273
  • COVID-19 Vaccines

Supplementary concepts

  • SARS-CoV-2 variants