In situ management of confirmed central venous catheter-related bacteremia

Pediatr Infect Dis J. 1987 Aug;6(8):729-34. doi: 10.1097/00006454-198708000-00007.


Thirty-one patients with suspected central venous catheter-related bacteremia were evaluated with comparative quantitative cultures of central venous and peripheral blood specimens. Using criteria developed from studies in bacteremic animals, 19 patients were confirmed to have catheter-related bacteremia. Antibiotic therapy was administered through the catheter (in situ therapy) in 17 of those patients to evaluate the feasibility of treating patients with true central venous catheter-related bacteremias without catheter removal. Bacteremia was successfully eradicated in 11 of 17 patients (65%), allowing 7 patients to retain their catheter a median of 157 days. This study validates the use of comparative quantitative blood cultures in the diagnosis of catheter-related bacteremia and indicates that in situ therapy is a rational alternative to catheter removal in patients with catheter-related bacteremia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria / growth & development
  • Bacteria / isolation & purification
  • Blood / microbiology
  • Catheterization, Central Venous / adverse effects*
  • Catheters, Indwelling
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Infant, Newborn
  • Rabbits
  • Sepsis / diagnosis
  • Sepsis / drug therapy*
  • Sepsis / etiology


  • Anti-Bacterial Agents