A Case of SAPHO Syndrome Complicated by Uveitis with Good Response to Both TNF Inhibitor and JAKinib

Ritasman Baisya; Meghna Gavali; Mudit Tyagi; Phani Kumar Devarasetti

doi:10.1155/2023/6201887

A Case of SAPHO Syndrome Complicated by Uveitis with Good Response to Both TNF Inhibitor and JAKinib

Case Rep Rheumatol. 2023 Jan 18:2023:6201887. doi: 10.1155/2023/6201887. eCollection 2023.

Authors

Ritasman Baisya¹, Meghna Gavali¹, Mudit Tyagi², Phani Kumar Devarasetti¹

Affiliations

¹ Department of Clinical Immunology and Rheumatology, Nizam's Institute of Medical Sciences (NIMS), Hyderabad, India.
² Vitreoretinal Diseases, LV Prasad Eye Institute, MS Ophthalmology, Hyderabad, India.

Abstract

Introduction: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory condition describing the constellation of inflammatory skin, bone, and joint manifestations which result in diagnostic difficulty and therapeutic challenge.

Case: Here, we present a case of a young male diagnosed with SAPHO syndrome with osteoarticular and cutaneous involvement from an early age in his life. He suffered diagnostic challenges for a long time and was hence inadequately treated. He had minimal response to conventional DMARDs but showed excellent response to TNF inhibitor (adalimumab). Later, he defaulted treatment and presented with acute anterior uveitis which was also dramatically improved with adalimumab and tofacitinib although financial constraint was always an issue for the patient.

Conclusion: The uniqueness of this case was that the patient had a multiorgan involvement including osteoarticular system, skin, and eye. Both TNFi (adalimumab) and JAKinib (tofacitinib) had a good response to all organs with a net improvement in the quality of life of this patient.

Publication types

Case Reports