Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesity: A 10-Year Follow-up of a Randomized Clinical Trial

doi:10.1001/jamainternmed.2022.6291

Randomized Controlled Trial

. 2023 Mar 1;183(3):272-275.

doi: 10.1001/jamainternmed.2022.6291.

Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesity: A 10-Year Follow-up of a Randomized Clinical Trial

Ying Chen¹, Zheng Chen², Lingling Pan³, Zhi-Min Ma⁴, Huijie Zhang⁵, Xue-Jun Li², Xiaoying Li^{1

6}

Affiliations

¹ Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
² Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
³ Department of Endocrinology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
⁴ Department of Endocrinology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Jiangsu, China.
⁵ Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
⁶ Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.

PMID: 36716009
PMCID: PMC9887527
DOI: 10.1001/jamainternmed.2022.6291

Randomized Controlled Trial

Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesity: A 10-Year Follow-up of a Randomized Clinical Trial

Ying Chen et al. JAMA Intern Med. 2023.

. 2023 Mar 1;183(3):272-275.

doi: 10.1001/jamainternmed.2022.6291.

Authors

Ying Chen¹, Zheng Chen², Lingling Pan³, Zhi-Min Ma⁴, Huijie Zhang⁵, Xue-Jun Li², Xiaoying Li^{1

6}

Affiliations

¹ Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
² Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
³ Department of Endocrinology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
⁴ Department of Endocrinology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Jiangsu, China.
⁵ Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
⁶ Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.

PMID: 36716009
PMCID: PMC9887527
DOI: 10.1001/jamainternmed.2022.6291

No abstract available

Plain language summary

This randomized clinical trial assesses the long-term effect of vigorous and moderate exercise on incident diabetes over a 10-year follow-up after a 12-month exercise intervention.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

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References

1. Knowler WC, Barrett-Connor E, Fowler SE, et al. ; Diabetes Prevention Program Research Group . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. doi:10.1056/NEJMoa012512 - DOI - PMC - PubMed
1. Li G, Zhang P, Wang J, et al. . The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008;371(9626):1783-1789. doi:10.1016/S0140-6736(08)60766-7 - DOI - PubMed
1. Tuomilehto J, Lindström J, Eriksson JG, et al. ; Finnish Diabetes Prevention Study Group . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343-1350. doi:10.1056/NEJM200105033441801 - DOI - PubMed
1. Zhang HJ, He J, Pan LL, et al. . Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: a randomized clinical trial. JAMA Intern Med. 2016;176(8):1074-1082. doi:10.1001/jamainternmed.2016.3202 - DOI - PubMed
1. Zhang HJ, Pan LL, Ma ZM, et al. . Long-term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults: a 1-year follow-up study. Diabetes Obes Metab. 2017;19(2):284-289. doi:10.1111/dom.12809 - DOI - PubMed

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[1] Knowler WC, Barrett-Connor E, Fowler SE, et al. ; Diabetes Prevention Program Research Group . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. doi:10.1056/NEJMoa012512 - DOI - PMC - PubMed

[2] Knowler WC, Barrett-Connor E, Fowler SE, et al. ; Diabetes Prevention Program Research Group . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. doi:10.1056/NEJMoa012512 - DOI - PMC - PubMed

[3] Li G, Zhang P, Wang J, et al. . The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008;371(9626):1783-1789. doi:10.1016/S0140-6736(08)60766-7 - DOI - PubMed

[4] Li G, Zhang P, Wang J, et al. . The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008;371(9626):1783-1789. doi:10.1016/S0140-6736(08)60766-7 - DOI - PubMed

[5] Tuomilehto J, Lindström J, Eriksson JG, et al. ; Finnish Diabetes Prevention Study Group . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343-1350. doi:10.1056/NEJM200105033441801 - DOI - PubMed

[6] Tuomilehto J, Lindström J, Eriksson JG, et al. ; Finnish Diabetes Prevention Study Group . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343-1350. doi:10.1056/NEJM200105033441801 - DOI - PubMed

[7] Zhang HJ, He J, Pan LL, et al. . Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: a randomized clinical trial. JAMA Intern Med. 2016;176(8):1074-1082. doi:10.1001/jamainternmed.2016.3202 - DOI - PubMed

[8] Zhang HJ, He J, Pan LL, et al. . Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: a randomized clinical trial. JAMA Intern Med. 2016;176(8):1074-1082. doi:10.1001/jamainternmed.2016.3202 - DOI - PubMed

[9] Zhang HJ, Pan LL, Ma ZM, et al. . Long-term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults: a 1-year follow-up study. Diabetes Obes Metab. 2017;19(2):284-289. doi:10.1111/dom.12809 - DOI - PubMed

[10] Zhang HJ, Pan LL, Ma ZM, et al. . Long-term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults: a 1-year follow-up study. Diabetes Obes Metab. 2017;19(2):284-289. doi:10.1111/dom.12809 - DOI - PubMed

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Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesity: A 10-Year Follow-up of a Randomized Clinical Trial

Affiliations

Effect of Moderate and Vigorous Aerobic Exercise on Incident Diabetes in Adults With Obesity: A 10-Year Follow-up of a Randomized Clinical Trial

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Conflict of interest statement

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