Factors associated with ever using cannabidiol in a cohort of younger pregnant people

Neurotoxicol Teratol. 2023 Mar-Apr;96:107162. doi: 10.1016/j.ntt.2023.107162. Epub 2023 Jan 27.


One in four Americans have used cannabidiol (CBD) products in the past year, and use has become prevalent in many Western countries with recent deregulation from a controlled or illicit substance to an unrestricted product. CBD is also marketed to pregnant people to treat common medical conditions. However, preclinical work has linked cannabidiol exposure to embryotoxicity, as well as neuroendocrine, reproductive, and behavioral effects in offspring. No studies have examined the prevalence or correlates of CBD use among pregnant people. Demographic, medical, and psychosocial correlates of cannabidiol use were examined in the YoungMoms study, a cohort of pregnant people under the age of 22, a population that is at high risk for cannabis use during pregnancy. Few of the participants (n = 186; 75% Black or Biracial) reported use of cannabidiol during pregnancy, but one in five had tried these products. Participants who reported ever using CBD were more likely to report alcohol and other drug use prior to pregnancy, controlling for race.As the use of CBD among people of reproductive age is increasingly prevalent, more research on CBD use in pregnant human populations is needed to investigate the effects of CBD on fetal development and infant outcomes.

Keywords: CBD; Cannabidiol; Cannabinoid; Pregnancy; Prenatal; Prenatal cannabis.

MeSH terms

  • Cannabidiol* / pharmacology
  • Cannabidiol* / therapeutic use
  • Cannabis* / adverse effects
  • Female
  • Humans
  • Infant
  • Pregnancy
  • United States


  • Cannabidiol