[Effect of Broncho-Vaxom on serum IgE and IgG levels in patients with bronchial asthma and chronic obstructive lung disease. A placebo-controlled double-blind study]

Schweiz Med Wochenschr. 1987 Sep 26;117(39):1514-8.
[Article in German]


In a double-blind study of 33 patients with bronchial asthma or chronic obstructive pulmonary disease, of whom 17 had proven atopies, the results showed a distinct diminution of the mean IgE level in the atopic patients at the end of 1-month treatment with Broncho-Vaxom, though not attaining statistical significance (trend with p less than 0.10), compared to a slight increase under placebo. Simultaneously the mean IgG level increased slightly in the atopic patients under Broncho-Vaxom and remained stable in the patients under placebo (p less than 0.10). The IgE and IgG values of the non-atopic patients in both treatment groups remained practically unchanged. Considering the small number of patients in each group, and the clear tendency towards a diminution of the IgE level, it may be concluded that the administration of Broncho-Vaxom to atopic patients does not lead to an increased IgE level but, on the contrary, seems rather to favour a decrease.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Adult
  • Aged
  • Asthma / immunology*
  • Asthma / therapy
  • Bacteria*
  • Cell Extracts*
  • Double-Blind Method
  • Female
  • Humans
  • Immunoglobulin E / analysis*
  • Immunoglobulin G / analysis*
  • Lung Diseases, Obstructive / immunology*
  • Lung Diseases, Obstructive / therapy
  • Male
  • Middle Aged
  • Respiratory Function Tests


  • Adjuvants, Immunologic
  • Broncho-Vaxom
  • Cell Extracts
  • Immunoglobulin G
  • Immunoglobulin E