Differentiation syndrome in patients with acute promyelocytic leukemia

Nusiba H Elamin; Farah Rashid; Muhammad S Afana; Honar Cherif; Mohamed A Yassin

doi:10.1002/ccr3.6697

Differentiation syndrome in patients with acute promyelocytic leukemia

Clin Case Rep. 2023 Jan 26;11(1):e6697. doi: 10.1002/ccr3.6697. eCollection 2023 Jan.

Authors

Nusiba H Elamin¹, Farah Rashid¹, Muhammad S Afana², Honar Cherif², Mohamed A Yassin²

Affiliations

¹ Department of Internal Medicine Hamad General Hospital, Hamad Medical Corporation Doha Qatar.
² Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research Hamad Medical Corporation Doha Qatar.

Abstract

A 48-year-old male diagnosed with acute promyelocytic leukemia (APL) started on all-trans-retinoic acid and arsenic trioxide, developed typical symptoms of differentiation syndrome, and improved dramatically on steroids. Hence, any APL patient started on chemotherapy, needs to be monitored closely for developing differentiation syndrome and to start steroid upon suspicion.

Keywords: ATRA syndrome; acute leukemia; steroids.

Publication types

Case Reports