Differentiation syndrome in patients with acute promyelocytic leukemia

Clin Case Rep. 2023 Jan 26;11(1):e6697. doi: 10.1002/ccr3.6697. eCollection 2023 Jan.


A 48-year-old male diagnosed with acute promyelocytic leukemia (APL) started on all-trans-retinoic acid and arsenic trioxide, developed typical symptoms of differentiation syndrome, and improved dramatically on steroids. Hence, any APL patient started on chemotherapy, needs to be monitored closely for developing differentiation syndrome and to start steroid upon suspicion.

Keywords: ATRA syndrome; acute leukemia; steroids.

Publication types

  • Case Reports