Plum supplementation and lipid profile: a systematic review and meta-analysis of randomised controlled trials

J Nutr Sci. 2023 Jan 16:12:e6. doi: 10.1017/jns.2022.101. eCollection 2023.

Abstract

Plums are abundant in bioactive compounds which have been associated with numerous health benefits. In the present study, we aimed at examining the impact of plum supplementation on lipid profile of individuals. Electronic bibliographical databases were searched for relevant randomised clinical trials. Articles meeting our eligibility criteria were included for data extraction and final analysis. Weighted mean difference (WMD) was estimated using a random-effect model. Of the total articles retrieved in the initial search, nine articles were found to be eligible to be included in the analysis. Our results show that plum supplementation significantly improves total cholesterols levels in the unhealthy individuals. Moreover, plum supplementation reduces the LDL-c levels in the pooled sample (WMD = -11⋅52 mg/dl; 95 % CI -21⋅93, -1⋅11, P = 0⋅03, I 2 = 98⋅7 %) and also in some of the subgroups of individuals (dried plum, unhealthy subjects, duration more than 8 weeks). Moreover, it had a significant reducing effect on TC levels just in unhealthy subjects. Although plum supplementation did not have any significant impact on serum levels of TG nor HDL-c. Our results show that supplementation with plums is potentially effective in reducing serum total cholesterol and LDL-c.

Keywords: Lipid profile; Meta-analysis; Plum; Randomised controlled trials.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Cholesterol, LDL
  • Dietary Supplements
  • Humans
  • Prunus domestica*
  • Randomized Controlled Trials as Topic

Substances

  • Cholesterol, LDL