Fish Collagen Peptide (NaticolⓇ) Protects the Skin from Dryness, Wrinkle Formation, and Melanogenesis Both In Vitro and In Vivo

Minhee Lee; Dakyung Kim; Seong-Hoo Park; Jaeeun Jung; Wonhee Cho; A Ram Yu; Jeongmin Lee

doi:10.3746/pnf.2022.27.4.423

Fish Collagen Peptide (Naticol^Ⓡ) Protects the Skin from Dryness, Wrinkle Formation, and Melanogenesis Both In Vitro and In Vivo

Prev Nutr Food Sci. 2022 Dec 31;27(4):423-435. doi: 10.3746/pnf.2022.27.4.423.

Authors

Minhee Lee¹, Dakyung Kim¹, Seong-Hoo Park¹, Jaeeun Jung¹, Wonhee Cho¹, A Ram Yu^{2

3}, Jeongmin Lee^{1

4}

Affiliations

¹ Department of Medical Nutrition, Kyung Hee University, Gyeonggi 17104, Korea.
² Department of Plant Science and Technology, Chung-Ang University, Gyeonggi 17546, Korea.
³ Technical Assistance Department, The Food Industry Promotional Agency of Korea, Jeonbuk 54576, Korea.
⁴ Clinical Nutrition Institute, Kyung Hee University, Seoul 02447, Korea.

Abstract

Consistent ultraviolet B (UVB) radiation exposure results in dry skin, wrinkles, and melanogenesis. In this study, we investigated whether fish collagen peptide (Naticol^Ⓡ) could inhibit photoaging and oxidative stress in skin exposed to UVB using cell and animal models. We measured the skin hydration, histological observations, antioxidant activities, moisturizing-related factors, collagen synthesis-related factors, and melanogenesis-related factors in skin cells and animal skin using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blot assay. Naticol^Ⓡ collagen improved skin moisturization via hyaluronic acid and ceramide synthesis-related factors in HaCaT cells and SHK-I hairless mice that were exposed to UVB. In addition, Naticol^Ⓡ collagen inhibited wrinkle formation in Hs27 cells and SHK-I hairless mice exposed to UVB and restrained melanogenesis in 3-isobutyl-1-methylxanthine-induced B16F10 cells and UVB-irradiated SHK-I hairless mice. On the basis of these findings, we propose that ingestion of Naticol ^Ⓡ collagen might be valuable for preventing skin photoaging.

Keywords: fish collagen peptide; skin health; ultraviolet B.