Methylated ZNF582: a therapeutic target in oral cancer

Epigenomics. 2022 Nov;14(22):1389-1392. doi: 10.2217/epi-2022-0368. Epub 2023 Feb 1.

Abstract

Tweetable abstract Zinc finger proteins control the transcription of downstream genes that are implicated in migration, invasion, cell death and proliferation. More mechanistic research on ZNF582 is needed to ascertain how this protein's methylation regulates the inflammatory pathway in oral cancer.

Keywords: ZNF582; epigenetics; methylation; oral cancer; zinc finger proteins.

MeSH terms

  • DNA Methylation
  • Humans
  • Kruppel-Like Transcription Factors* / genetics
  • Mouth Neoplasms* / drug therapy
  • Mouth Neoplasms* / genetics
  • Paired Box Transcription Factors / genetics
  • Paired Box Transcription Factors / metabolism

Substances

  • Kruppel-Like Transcription Factors
  • Paired Box Transcription Factors
  • ZNF582 protein, human