The diagnosis of progressive multifocal leukoencephalopathy (PML) is based on a combination of clinical, radiographic, and laboratory findings. However, negative JC polyomavirus (JCPyV) PCR in CSF does not always rule out JCPyV-related PML. In this narrative review, we sought to examine the characteristic of biopsy-proven PML in patients with undetectable JCPyV CSF PCR and provide alternative approaches in this scenario.
Keywords: BK virus; Brainstem; Cerebellum; JC virus; Posterior fossa; Progressive multifocal leukoencephalopathy.
© 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.