Undetectable JC virus CSF PCR in patients with JC virus-induced progressive multifocal leukoencephalopathy

J Neurovirol. 2023 Feb;29(1):94-99. doi: 10.1007/s13365-023-01113-7. Epub 2023 Feb 1.


The diagnosis of progressive multifocal leukoencephalopathy (PML) is based on a combination of clinical, radiographic, and laboratory findings. However, negative JC polyomavirus (JCPyV) PCR in CSF does not always rule out JCPyV-related PML. In this narrative review, we sought to examine the characteristic of biopsy-proven PML in patients with undetectable JCPyV CSF PCR and provide alternative approaches in this scenario.

Keywords: BK virus; Brainstem; Cerebellum; JC virus; Posterior fossa; Progressive multifocal leukoencephalopathy.

Publication types

  • Review

MeSH terms

  • Humans
  • JC Virus* / genetics
  • Leukoencephalopathy, Progressive Multifocal*
  • Polymerase Chain Reaction