Epidemiology of mental health comorbidity in patients with psoriasis: An analysis of trends from 1986 to 2019

Psychiatry Res. 2023 Mar;321:115078. doi: 10.1016/j.psychres.2023.115078. Epub 2023 Jan 25.


Background: The prevalence of mental disorders such as depression, anxiety, and suicide has increased in patients with psoriasis, although no study has systematically analyzed the epidemiology worldwide.

Objective: To explore the prevalence and incidence of psoriasis with comorbid mental disorders (i.e., depression, anxiety, and suicide).

Methods: Five databases from establishment through May 2022 were searched. Stata SE 15.1 was used for the data analysis. Subgroup, meta-regression, and sensitivity analyses were used to evaluate the heterogeneity of pooled studies.

Results: We evaluated 56 studies in our research. The prevalence of depression, anxiety, and suicide in adults with psoriasis was 20%, 21%, and 0.77%. Patients with psoriasis in North America had a higher prevalence of depression and suicide, whereas those in South America had a higher prevalence of anxiety. The incidence of depression, anxiety, and suicide was 42.1, 24.7, and 2.6 per 1000 person-years in adults with psoriasis, respectively.

Limitations: All of the included studies were published in Chinese and English, causing a degree of selection bias.

Conclusion: These findings demonstrate the incidence and prevalence of comorbid mental disorders in patients with psoriasis, which may raise awareness among physicians and patients regarding the mental problems associated with psoriasis.

Keywords: Comorbidity; Epidemiology; Mental health; Psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anxiety / epidemiology
  • Comorbidity
  • Depression / psychology
  • Humans
  • Mental Health
  • Prevalence
  • Psoriasis* / epidemiology
  • Suicide* / psychology