Ocular Cicatricial Pemphigoid With IgM-Positive Biopsy

Cornea. 2023 Dec 1;42(12):1503-1505. doi: 10.1097/ICO.0000000000003235. Epub 2023 Jan 10.


Purpose: The aim of this study was to investigate the prevalence of IgM along the basement membrane zone (BMZ) of patients with ocular cicatricial pemphigoid (OCP) and the outcomes of these patients with immunomodulatory therapy.

Methods: This study is a retrospective chart review of patients with conjunctival biopsy-proven OCP. Clinical data, including the presence of linear IgM deposition along the BMZ on either direct immunofluorescence or avidin-biotin complex immunohistochemistry, were recorded. Response to IMT was also recorded.

Results: A total of 817 patients with documented conjunctival biopsies were identified, with 93 (11.4%) positive for OCP with linear IgM deposition along the BMZ. Forty-six patients with sufficient follow-up were evaluated for clinical outcomes, with 35 (76.1%) able to achieve durable remission an average of 24.3 months after initiation of IMT. Most of these patients, 82.9%, were able to achieve durable remission with first-line antimetabolite therapy. Three patients were identified with solely IgM-positive conjunctival biopsies.

Conclusions: Our study suggests that IgM positivity is seen in a minority of patients with OCP and that outcomes are comparable for these patients to the general OCP patient population.

MeSH terms

  • Biopsy
  • Conjunctiva / pathology
  • Humans
  • Immunoglobulin M
  • Pemphigoid, Benign Mucous Membrane* / drug therapy
  • Retrospective Studies


  • Immunoglobulin M