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Case Reports
. 2023 Apr 1;48(4):e165-e166.
doi: 10.1097/RLU.0000000000004513. Epub 2023 Feb 1.

Retroperitoneal Inflammation Detected on FDG PET/CT in Patient on Long-Term Immunotherapy

Tasnim Khessib  1 , Benjamin Franc  1 , Eric Yang  2 , Farshad Moradi  1
Affiliations
Case Reports

Retroperitoneal Inflammation Detected on FDG PET/CT in Patient on Long-Term Immunotherapy

Tasnim Khessib et al. Clin Nucl Med. .

Abstract

A 68-year-old man with a history of pulmonary adenocarcinoma on maintenance pembrolizumab presented for surveillance imaging. 18 F-FDG PET/CT demonstrated new ill-defined right retroperitoneal and presacral soft tissue stranding with associated FDG uptake suggestive of inflammation. Biopsy results revealed fibroadipose tissue with extensive lymphoplasmacytic inflammation concerning for immunotherapy-related toxicity. The patient was subsequently taken off pembrolizumab, which he had been on for approximately 3 years. Recognition of immunotherapy-related adverse effects and how they can manifest on 18 F-FDG PET/CT is important for prompt cessation of treatment.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

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