Successful Treatment of Persistent 5-Nitroimidazole-Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid

Candice J McNeil; John C Williamson; Christina A Muzny

doi:10.1097/OLQ.0000000000001741

Successful Treatment of Persistent 5-Nitroimidazole-Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid

Sex Transm Dis. 2023 Apr 1;50(4):243-246. doi: 10.1097/OLQ.0000000000001741. Epub 2022 Nov 29.

Authors

Candice J McNeil¹, John C Williamson¹, Christina A Muzny²

Affiliations

¹ From the Section on Infectious Diseases, Wake Forest University School of Medicine, Winston Salem, NC.
² Division of Infectious Diseases, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL.

Abstract

We describe a case of persistent 5-nitroimidazole-resistant trichomoniasis cured after 14 days of oral secnidazole and intravaginal boric acid. Secnidazole may be an important treatment option for resistant trichomoniasis, particularly in women who fail other regimens, including higher doses of oral metronidazole and tinidazole for longer durations of time.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Metronidazole / therapeutic use
Tinidazole / pharmacology
Tinidazole / therapeutic use
Trichomonas Infections* / drug therapy
Trichomonas Vaginitis* / drug therapy

Substances

secnidazole
Metronidazole
4-nitroimidazole
boric acid
Tinidazole