Regeneration of immature incisor using platelet rich fibrin: report of a novel clinical application

BMC Oral Health. 2023 Feb 2;23(1):69. doi: 10.1186/s12903-023-02759-9.


Background: Endodontic treatment of young permanent teeth with necrotic pulp presents a clinical challenge for the dentist, and conventional endodontic treatment will result in tooth fracture along with a poor prognosis. Regenerative endodontics is a new protocol that has been advanced in the last decades for managing immature permanent teeth. Rare successful management of immature permanent incisors using platelet-rich fibrin is a technique-sensitive procedure.

Case presentation: A 08 years 04 months old female reported the chief complaint of pain in the upper front tooth region for one week. A blunderbuss canal was identified on radiographic examination, and revascularization using platelet-rich fibrin was planned and adopted. After the treatment, apical closure and root lengthening were noted without complications during subsequent follow-ups. Complete periapical healing with greater than 1.5 cm of dentinal thickness was noted.

Conclusion: Revascularization can be considered a viable treatment option for immature nonvital permanent teeth; with advancements in regenerative medicine and clinical practices, revascularization therapies could be developed as a novel mode of treatment in non-vital and dental traumatic cases.

Keywords: Nonvital tooth; Regenerative endodontics; Tooth apex; Trauma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dental Pulp Necrosis / therapy
  • Dentition, Permanent
  • Female
  • Humans
  • Incisor
  • Infant
  • Platelet-Rich Fibrin*
  • Regeneration
  • Root Canal Therapy / methods