Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation

Structure. 2023 Feb 2;31(2):121-122. doi: 10.1016/j.str.2023.01.004.


In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to therapeutically target critical viral functions necessary for host immune-response suppression.

Publication types

  • Comment

MeSH terms

  • COVID-19*
  • Humans
  • SARS-CoV-2* / metabolism
  • Viral Nonstructural Proteins / chemistry


  • Viral Nonstructural Proteins