Recognition of transcription terminators during retrotransposition: How to keep a group II intron quiet

Daniel B Haack; Navtej Toor

doi:10.1016/j.molcel.2022.12.027

Recognition of transcription terminators during retrotransposition: How to keep a group II intron quiet

Mol Cell. 2023 Feb 2;83(3):332-334. doi: 10.1016/j.molcel.2022.12.027.

Authors

Daniel B Haack¹, Navtej Toor²

Affiliations

¹ Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
² Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ntoor@ucsd.edu.

PMID: 36736308
DOI: 10.1016/j.molcel.2022.12.027

Abstract

Chung et al. recently presented the structure of a primitive group IIC intron with its DNA target, which reveals the structural requirements that this class of intron uses to recognize a transcription terminator stem loop at the DNA level for insertion during retrotransposition.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Base Sequence
DNA*
DNA, Bacterial / genetics
Introns / genetics
Terminator Regions, Genetic / genetics
Transcription, Genetic*

Substances

DNA, Bacterial
DNA

Grants and funding

R35 GM141706/GM/NIGMS NIH HHS/United States