Evaluation of carboxylic acid-derivatized corroles as novel gram-positive antibacterial agents under non-photodynamic inactivation conditions

Bioorg Med Chem Lett. 2023 Feb 15:82:129167. doi: 10.1016/j.bmcl.2023.129167. Epub 2023 Feb 2.

Abstract

Herein, we report the synthesis and evaluation of carboxylic acid corroles bearing either one, two, three of four carboxylic groups as gram-positive antibacterial agents against two strains of S. aureus, one methicillin-sensible (MSSA) and the other methicillin-resistant (MRSA). Lead compounds 5 and 6 show low minimum inhibitory concentrations (MICs) of 0.78 μg/mL against both MSSA and MRSA. These molecules, previously underexplored as antibacterial agents, can now serve as a new scaffold for antimicrobial development.

Keywords: Corrole; Gram-positive antibacterial activity; MRSA; MSSA; S. aureus; Structure–activity relationships SAR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Carboxylic Acids / pharmacology
  • Methicillin
  • Methicillin-Resistant Staphylococcus aureus*
  • Microbial Sensitivity Tests
  • Porphyrins
  • Staphylococcus aureus

Substances

  • Anti-Bacterial Agents
  • Carboxylic Acids
  • Methicillin
  • corrole
  • Porphyrins