The relationship between degree of coronary artery stenosis detected by coronary computed tomography angiography and ACEF risk score in patients with chronic coronary syndrome

Ann Saudi Med. 2023 Jan-Feb;43(1):35-41. doi: 10.5144/0256-4947.2023.35. Epub 2023 Feb 2.

Abstract

Background: The ACEF risk score (age, creatinine, and ejection fraction) has been associated with satisfactory predictive values not only for short-term and long-term mortality but also for major adverse cardiovascular events.

Objectives: Investigate the relationship between ACEF risk score and degree of coronary artery stenosis.

Design: Retrospective, observational study.

Setting: Tertiary percutaneous coronary intervention center.

Patients and methods: In patients with coronary coronary artery stenosis <70% were compared with patients with stenosis ≥70%. All were diagnosed with chronic coronary syndrome (CCS) and had undergone coronary computed tomography angiography (CTA). Receiver operating characteristic analysis was performed for the cut-off value of the ACEF risk score. Univariable and multivariable regression analyses were performed for significant parameters related to degree of coronary artery stenosis in coronary CTA.

Main outcome measures: Relationship between ACEF risk score and degree of coronary artery stenosis in coronary CTA.

Sample size: 148 patients.

Results: In the multivariable regression analysis; left ventricular ejection fraction (OR: 0.94; 95%CI: 0.89-0.99, P=.015) and ACEF risk score (OR: 5.63; 95% CI: 1.62-19.57, P=.007) were independent predictors for degree of coronary artery stenosis. The ACEF risk score was statistically significantly higher in with patients with stenosis ≥70% (1.43 [0.59]) than in patients with stenosis <70% (0.98 [0.35]), P<.001). An ACEF risk score value >1.04 was a predictor of the presence of severe coronary artery stenosis detected by coronary CTA in patients with CCS, with 66% sensitivity and 69% specificity.

Conclusions: A high ACEF risk score (age, creatinine, ejection fraction) in patients with CCS is associated with the presence of severe coronary artery stenosis detected by coronary CTA, and was useful as an assessment tool for coronary angiography in patients with CCS.

Limitations: Since we do not have long-term follow-up results, we do not know the prognostic value of the ACEF risk score in the long-term follow-up of patients with CCS.

Conflict of interest: None.

Publication types

  • Observational Study

MeSH terms

  • Computed Tomography Angiography
  • Constriction, Pathologic
  • Coronary Angiography
  • Coronary Artery Disease*
  • Coronary Stenosis* / diagnostic imaging
  • Creatinine
  • Humans
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Assessment / methods
  • Risk Factors
  • Stroke Volume
  • Syndrome
  • Ventricular Function, Left

Substances

  • Creatinine

Grants and funding

Funding: None.