Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population

PeerJ. 2023 Jan 30:11:e14740. doi: 10.7717/peerj.14740. eCollection 2023.

Abstract

Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20-1.95], P = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27-1.78], P < 0.001) and IFIH1 rs10930046-C allele (additive model: adjusted OR = 1.26, 95% CI [1.07-1.49], P = 0.005) were associated with chronic hepatitis C (CHC). And the risk of CHC increased in people carrying more unfavorable genotypes (rs2074158-AG/GG or rs10930046-CC), with the chronic rates for genotypes number from zero to two in 60.69%, 57.33%, and 85.93%, respectively (adjusted OR = 3.64, 95% CI [2.18-6.08]; P < 0.001). Genetic polymorphism of IFIH1 and DHX58 may be related to CHC in the Chinese Han population. Furthermore, the risk of CHC increases as the number of unfavorable genotypes carried by the HCV-infected person increases. IFIH1 rs10930046, DHX58 rs2074158, age, ALT, and AST levels were all independent predictors of CHC.

Keywords: Chronicity; DHX58; Hepatitis C; IFIH1; Polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • East Asian People
  • Hepacivirus* / genetics
  • Hepatitis C* / genetics
  • Humans
  • Interferon-Induced Helicase, IFIH1 / genetics
  • Polymorphism, Single Nucleotide / genetics
  • RNA Helicases / genetics

Substances

  • Interferon-Induced Helicase, IFIH1
  • IFIH1 protein, human
  • DHX58 protein, human
  • RNA Helicases

Grants and funding

All external funding or support received during this research was from the Open Research Fund Program of the State Key Laboratory of Virology of China (2021KF008) (PH), the Outstanding Youth Fund Project of Jiangsu Province (BK20190126), the Natural Science Foundation of Yunnan Province (2019FA005) (PH), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.