Physiology Reconfigured: How Does Bariatric Surgery Lead to Diabetes Remission?

Endocrinol Metab Clin North Am. 2023 Mar;52(1):49-64. doi: 10.1016/j.ecl.2022.06.003. Epub 2022 Nov 14.


Bariatric surgery improves glucose homeostasis and glycemic control in patients with type 2 diabetes. Over the past 20 years, a breadth of studies has been conducted in humans and rodents aimed to identify the regulatory nodes responsible for surgical remission of type 2 diabetes. The review herein discusses central mechanisms of type 2 diabetes remission associated with weight loss and surgical modification of the gastrointestinal tract.

Keywords: Bariatric surgery; Cardiovascular risk; Diabetes; Metabolic surgery; Obesity.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Bariatric Surgery*
  • Blood Glucose
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / surgery
  • Humans
  • Obesity / complications
  • Treatment Outcome
  • Weight Loss


  • Blood Glucose