Autophagy-dependent ferroptosis in kidney disease

Yuanting Yang; Jiayi Cheng; Qisheng Lin; Zhaohui Ni

doi:10.3389/fmed.2022.1071864

Autophagy-dependent ferroptosis in kidney disease

Front Med (Lausanne). 2023 Jan 23:9:1071864. doi: 10.3389/fmed.2022.1071864. eCollection 2022.

Authors

Yuanting Yang¹, Jiayi Cheng², Qisheng Lin¹, Zhaohui Ni¹

Affiliations

¹ Molecular Cell Lab for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Tianping Community Health Service Center, Shanghai, China.

Abstract

Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc^-), lipid metabolism, and iron metabolism pathways. Recent studies have reported that autophagy-dependent ferroptosis (ferroptosis meditated by ferritinophagy, lipophagy, and clockophagy) plays a significant role in the occurrence of several diseases, including diseases affecting the nerves, liver, lungs, and kidneys. This review provides an overview of research progress made on autophagy-dependent ferroptosis in kidney diseases.

Keywords: acute kidney injury; autophagy; cell death; ferroptosis; kidney disease.

Publication types

Review

Grants and funding

This review was supported by the National Natural Science Foundation of (Nos. 82070693, 82200751, 81770666, and 81570604); Clinical Research Plan of SHDC (No. SHDC2020CR3029B); Shanghai Sailing Program (No. 22YF1423400); and China Postdoctoral Science Foundation (No. 2022M712112).