Large animal models in the study of gynecological diseases

Minghua Cui; Yuehui Liu; Xiaoping Men; Tao Li; Da Liu; Yongzhi Deng

doi:10.3389/fcell.2023.1110551

Large animal models in the study of gynecological diseases

Front Cell Dev Biol. 2023 Jan 23:11:1110551. doi: 10.3389/fcell.2023.1110551. eCollection 2023.

Authors

Minghua Cui¹, Yuehui Liu², Xiaoping Men², Tao Li³, Da Liu⁴, Yongzhi Deng⁵

Affiliations

¹ Gynecology Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
² Laboratory Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
³ Department of Acupuncture and Massage, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
⁴ School of Pharmacy, Changchun University of Chinese Medicine, Changchun, Jilin, China.
⁵ The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.

Abstract

Gynecological diseases are a series of diseases caused by abnormalities in the female reproductive organs or breast, which endanger women's fertility and even their lives. Therefore, it is important to investigate the mechanism of occurrence and treatment of gynecological diseases. Animal models are the main objects for people to study the development of diseases and explore treatment options. Large animals, compared to small rodents, have reproductive organs with structural and physiological characteristics closer to those of humans, and are also better suited for long-term serial examinations for gynecological disease studies. This review gives examples of large animal models in gynecological diseases and provides a reference for the selection of animal models for gynecological diseases.

Keywords: endometriosis; gestational diabetes mellitus; gynecological diseases; large animal models; polycystic ovary syndrome.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81973712), Jilin Province Science and Technology Development Program in China (Grant No. 20210204013YY), Jilin Province Science and Technology Development Plan Program (Grant No. 20210204013YY, 20210101192JC, 20200504005YY) and Jilin Provincial Development and Reform Commission Program (2023C027-3).