Stoking inflammasome fires in the COVID-19 neighborhood

Larisa I Labzin; Kate Schroder

doi:10.1016/j.chom.2023.01.008

Stoking inflammasome fires in the COVID-19 neighborhood

Cell Host Microbe. 2023 Feb 8;31(2):168-170. doi: 10.1016/j.chom.2023.01.008.

Authors

Larisa I Labzin¹, Kate Schroder²

Affiliations

¹ Institute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, QLD, Australia; IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia. Electronic address: l.labzin@uq.edu.au.
² Institute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, QLD, Australia; IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, QLD, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia. Electronic address: k.schroder@uq.edu.au.

Abstract

The cellular and molecular sources of elevated IL-1β and IL-6 in COVID-19 remain unclear. In this issue of Cell Host and Microbe, Barnett et al. determine how immune cells sense SARS-CoV-2 infection in neighboring epithelial cells to trigger inflammasome signaling and IL-1β release, which in turn promotes IL-6 release.

Publication types

Comment

MeSH terms

COVID-19*
Humans
Inflammasomes*
Interleukin-1beta
Interleukin-6
NLR Family, Pyrin Domain-Containing 3 Protein
SARS-CoV-2

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Interleukin-6
Interleukin-1beta