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Review
. 2023 Jan 30;12(3):447.
doi: 10.3390/cells12030447.

Advances of Wnt Signalling Pathway in Colorectal Cancer

Yaoyao Zhu  1 , Xia Li  1   2
Affiliations
Review

Advances of Wnt Signalling Pathway in Colorectal Cancer

Yaoyao Zhu et al. Cells. .

Abstract

Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a high mortality rate despite the decreasing incidence and new diagnostic and therapeutic strategies. CRC arises from both epidemiologic and molecular backgrounds. In addition to hereditary factor and genetic mutations, the strongly varying incidence of CRC is closely linked to chronic inflammatory disorders of the intestine and terrible dietary habits. The Wnt signalling pathway is a complex regulatory network that is implicated in many CRC physiological processes, including cancer occurrence, development, prognosis, invasion, and metastasis. It is currently believed to include classical Wnt/β-catenin, Wnt/PCP, and Wnt/Ca2+. In this review, we summarise the recent mechanisms and potential regulators of the three branches of the Wnt signalling pathway in CRC.

Keywords: Wnt signalling pathway; cancer stem cells; colitis-associated carcinoma; colorectal cancer; invasion and metastasis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The canonical and non-canonical Wnt signalling pathway.
Figure 2
Figure 2
The Wnt signaling pathway in occurrence of colorectal cancer. Genetic factors, and environmental factors, such as unhealthy lifestyle, and imbalanced gut microbiota may induce colorectal cancer (CRC) by Wnt signaling pathway. Moreover, aberrant Wnt signaling pathway also play a crucial role colitis-associated carcinoma.
Figure 3
Figure 3
The Wnt signalling pathway in the biochemical process of colorectal cancer (CRC). The aberrant Wnt pathway drives the cancer stem cells, the tumour microenvironment, angiogenesis, invasion, metastasis, and drug resistance in CRC.
See this image and copyright information in PMC

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Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (No. 82273992 and 82073870).