Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors

Int J Mol Sci. 2023 Jan 22;24(3):2195. doi: 10.3390/ijms24032195.


Primary tumors of the airways in the pediatric population are very rare entities. For this reason, little is known about the pathogenesis of these neoplasms. Understanding the biology has different practical implications: for example, it could help in the differential diagnosis, have a prognostic significance, or may lead to the development of a targeted therapy. The aim of this article is to present the current knowledge about pediatric airways tumors, focusing on the molecular mechanisms that cause the onset and progression of these neoplasms. After a brief introduction of epidemiology and clinical presentation, the tumorigenesis of the most frequent pediatric airways tumors will be described: Juvenile-onset recurrent respiratory papillomatosis (JORRP), Subglottic Hemangiona (SH), Rhabdomyosarcoma (RMS), and Mucoepidermoid carcinoma (MEC).

Keywords: children; molecular mechanisms; mucoepidermoid carcinoma; pediatric airways tumors; pediatric laryngeal tumors; recurrent respiratory papillomatosis; rhabdomyosarcoma; subglottic hemangioma; tumor biology; tumorigenesis.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • Child
  • Humans
  • Papillomavirus Infections* / diagnosis
  • Respiratory System
  • Respiratory Tract Infections*

Grants and funding

This research received no external funding.