glp-1 Is Required in the Germ Line for Regulation of the Decision Between Mitosis and Meiosis in C. Elegans

Cell. 1987 Nov 20;51(4):589-99. doi: 10.1016/0092-8674(87)90128-0.

Abstract

In the wild-type C. elegans germ line there are both mitotic and meiotic germ cells. Mutations in glp-1 cause germ cells that would normally divide mitotically to enter meiosis. This mutant phenotype mimics the effect of killing the distal tip cell, a somatic cell that interacts with the germ line to regulate the mitotic/meiotic decision. In addition, wild-type glp-1 product is required maternally for embryogenesis. Temperature-shift experiments indicate that the temporal requirement for glp-1 activity in the germ line is the same as that for distal tip cell regulation. Mosaic analyses suggest that glp-1 is produced in the germ line. We propose that glp-1 acts as part of the receiving mechanism in the interaction between the distal tip cell and germ line.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caenorhabditis / embryology
  • Caenorhabditis / genetics*
  • Caenorhabditis / physiology
  • Disorders of Sex Development
  • Embryonic and Fetal Development
  • Genes*
  • Meiosis*
  • Mitosis*
  • Mutation
  • Temperature