On phenotyping with isoniazid: the use of urinary acetylation ratio and the uniqueness of antimodes. Study of two Amerindian populations

Clin Pharmacol Ther. 1987 Nov;42(5):493-7. doi: 10.1038/clpt.1987.186.

Abstract

Various conventions have been used to express the activity of polymorphic hepatic N-acetyltransferase of isoniazid. Among them, two of the most common are the "percentage of acetylisoniazid" and the "inactivation index." A third alternative convention is proposed, the "molar acetylation ratio," which showed the most clear-cut bimodal distribution when applied to the results obtained for Cuna and Teribe Amerindians living in Panama. Through this method a unique antimode was assigned to each Amerindian group and the same frequency of slow acetylators (24% to 29%) was found, unlike the results obtained by conventional approaches and antimodes derived from white populations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Acetyltransferases / metabolism
  • Adolescent
  • Adult
  • Female
  • Humans
  • Indians, Central American*
  • Isoniazid / analogs & derivatives
  • Isoniazid / urine*
  • Liver / enzymology
  • Male
  • Methods
  • Middle Aged
  • Panama
  • Phenotype
  • Time Factors

Substances

  • (N)1-acetylisoniazid
  • Acetyltransferases
  • Isoniazid