Mutations in Rv0678 Reduce Susceptibility of Mycobacterium tuberculosis to the DprE1 Inhibitor TBA-7371

Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0005223. doi: 10.1128/aac.00052-23. Epub 2023 Feb 14.

Authors

Deepak V Almeida¹, Paul J Converse¹, Eric L Nuermberger¹

Affiliation

¹ Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

No abstract available

Keywords: BTZ043; DprE1; Mycobacterium tuberculosis; OPC-167823; PBTZ169; Rv0678; TBA-7371.

Publication types

Letter
Comment

MeSH terms

Antitubercular Agents / pharmacology
Antitubercular Agents / therapeutic use
Bacterial Proteins / genetics
Humans
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis* / genetics
Tuberculosis, Multidrug-Resistant* / drug therapy

Substances

Antitubercular Agents
Bacterial Proteins