The ABC-associated Immunosenescence and Lifestyle Interventions in Autoimmune Disease

Pinglang Ruan; Susu Wang; Ming Yang; Haijing Wu

doi:10.2478/rir-2022-0021

The ABC-associated Immunosenescence and Lifestyle Interventions in Autoimmune Disease

Rheumatol Immunol Res. 2022 Oct 20;3(3):128-135. doi: 10.2478/rir-2022-0021. eCollection 2022 Oct.

Authors

Pinglang Ruan¹, Susu Wang², Ming Yang¹, Haijing Wu¹

Affiliations

¹ Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan Province, China.
² Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Abstract

Aging-associated immune changes, termed immunosenescence, occur with impaired robust immune responses. This immune response is closely related to a greater risk of development of autoimmune disease (AID), which results in increased levels of autoantibodies and increased morbidity and mortality. In addition, lifestyle-related risk factors play a pivotal role in AID, which may be probable via senescence-related immune cell subsets. Age-associated B cell (ABC) subsets have been observed in those who have rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and multiple sclerosis (MS). Here, this review aims to highlight the mechanisms of ABCs with lifestyle interventions in AID, especially how immunosenescence affects the pathogenesis of AID and the future of aging-associated lifestyle interventions in immunosenescence of AID.

Keywords: age-associated B cells; autoimmune disease; immunosenescence; lifestyle interventions.

Publication types

Review