Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology

J Natl Compr Canc Netw. 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006.


Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the female genital tract in the United States. It is estimated that 65,950 new uterine cancer cases will have occurred in 2022, with 12,550 deaths resulting from the disease. Endometrial carcinoma includes pure endometrioid cancer and carcinomas with high-risk endometrial histology (including uterine serous carcinoma, clear cell carcinoma, carcinosarcoma [also known as malignant mixed Müllerian tumor], and undifferentiated/dedifferentiated carcinoma). Stromal or mesenchymal sarcomas are uncommon subtypes accounting for approximately 3% of all uterine cancers. This selection from the NCCN Guidelines for Uterine Neoplasms focuses on the diagnosis, staging, and management of pure endometrioid carcinoma. The complete version of the NCCN Guidelines for Uterine Neoplasms is available online at NCCN.org.

Publication types

  • Practice Guideline

MeSH terms

  • Adenocarcinoma, Clear Cell*
  • Carcinoma, Endometrioid* / pathology
  • Carcinosarcoma* / diagnosis
  • Carcinosarcoma* / therapy
  • Endometrial Neoplasms* / diagnosis
  • Endometrial Neoplasms* / therapy
  • Female
  • Humans
  • Uterine Neoplasms* / diagnosis
  • Uterine Neoplasms* / pathology
  • Uterine Neoplasms* / therapy