Role of Laryngopharyngeal Reflux Changes in Children with Adenoid Hypertrophy: A Randomized Controlled Prospective Study

Yu Zhou; Ruixia Ma; Jiangbo Luo; Zhikai Wang; Pei Yang

doi:10.1155/2023/5628551

Role of Laryngopharyngeal Reflux Changes in Children with Adenoid Hypertrophy: A Randomized Controlled Prospective Study

Evid Based Complement Alternat Med. 2023 Feb 6:2023:5628551. doi: 10.1155/2023/5628551. eCollection 2023.

Authors

Yu Zhou¹, Ruixia Ma², Jiangbo Luo³, Zhikai Wang¹, Pei Yang¹

Affiliations

¹ Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750001, China.
² Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Yinchuan, Yinchuan, Ningxia 750001, China.
³ Department of Otorhinolaryngology Head and Neck Surgery, Ningxia Wuzhong Hongsipu District People's Hospital, Wuzhong, Ningxia 750001, China.

Abstract

Objectives: This prospective randomized controlled analysis aimed to assess the changes in laryngopharyngeal reflux (LPR) in children with adenoid hypertrophy (AH). Study design: a prospective, randomized, and controlled analysis.

Methods: The reflux symptom index (RSI) and the reflux finding score (RFS) scores were used to evaluate the laryngopharyngeal reflux changes in children diagnosed with adenoid hypertrophy. The pepsin concentration in salivary samples was examined, and the positive pepsin was used to assess the sensitivity and specificity of RSI, RFS, and RSI combined with RFS in forecasting LPR.

Results: In 43 children with AH, the sensitivity of the RSI and RFS scale (used alone or in combination) in diagnosing pharyngeal reflux in children with adenoid hypertrophy was lower. Pepsin expression was identified in 43 items of salivary samples, with a total positive rate of 69.77%, most of which were optimistic. The expression level of pepsin was positively correlated with the grade of adenoid hypertrophy (r = 0.576, P < 0.01). Based on the positive rate of pepsin, we found that the sensitivity and specificity of RSI and RFS were 5.77%, 35.03%, and 91.74%, 55.89%. Moreover, there was a noticeable distinction in the number of acid reflux episodes between the LPR-positive and LPR-negative groups.

Conclusion: There is a special connection between LPR change and children's AH. LPR exerts a crucial role in the progression of children's AH. Because of the low sensitivity of RSI and RFS, it is not suitable for LPR children to choose AH.