Association between autophagy and acute pancreatitis

Tao Zhang; Yu Gan; Shuai Zhu

doi:10.3389/fgene.2023.998035

Association between autophagy and acute pancreatitis

Front Genet. 2023 Jan 30:14:998035. doi: 10.3389/fgene.2023.998035. eCollection 2023.

Authors

Tao Zhang^{1

2

3}, Yu Gan⁴, Shuai Zhu^{1

2

3}

Affiliations

¹ Department of Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, China.
² Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
³ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
⁴ Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Autophagy pathway involves maintaining intracellular homeostasis by regulating the degradation of cytoplasmic components. Disfunction of autophagic process has been confirmed to be critical mechanism in many diseases, including cancer, inflammation, infection, degeneration and metabolic disorders. Recent studies have shown that autophagy is one of the early events in acute pancreatitis. Impaired autophagy promotes the abnormal activation of zymogen granules and results in apoptosis and necrosis of exocrine pancreas. Furthermore, multiple signal paths involve progression of acute pancreatitis by regulating autophagy pathway. This article provides a comprehensive review of the recent advances in epigenetic regulation of autophagy and the role of autophagy in acute pancreatitis.

Keywords: N6-methyladenosine; acute pancreatitis; advance; autophagy; mechanism.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81802450, No. 82273121) and Natural Science Foundation of Hunan Province of China (No. 2021JJ31135, No. 2022JJ20096).