Foldable capsular vitreous body indications, complications, and outcomes: a systematic review

Hashem Abu Serhan; Sara Irshaidat; Leen Abu Serhan; Ayman G Elnahry

doi:10.1007/s00417-023-05995-5

Foldable capsular vitreous body indications, complications, and outcomes: a systematic review

Graefes Arch Clin Exp Ophthalmol. 2023 Aug;261(8):2103-2116. doi: 10.1007/s00417-023-05995-5. Epub 2023 Feb 16.

Authors

Hashem Abu Serhan¹, Sara Irshaidat², Leen Abu Serhan³, Ayman G Elnahry^{4

5}

Affiliations

¹ Department of Ophthalmology, Hamad Medical Corporations, Doha, Qatar.
² Department of Pediatrics, King Hussein Cancer Centre, Amman, Jordan.
³ Hashemite University, Zarqa, Jordan.
⁴ Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt. ayman.elnahry@nih.gov.
⁵ Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, 10 Center Dr, Room 10D45, Bethesda, MD, 20892-2510, USA. ayman.elnahry@nih.gov.

PMID: 36795160
DOI: 10.1007/s00417-023-05995-5

Abstract

Purpose: Foldable capsular vitreous body (FCVB) is an emerging vitreous substitute that has been recently introduced to treat various advanced vitreoretinal conditions including severe ocular trauma, complicated retinal detachment (RD), and proliferative vitreoretinopathy.

Methods: Review protocol was prospectively registered at PROSPERO (CRD42022342310). A systematic literature search using PubMed, Ovid MEDLINE, and Google Scholar for articles published until May 2022 was performed. The search included the following keywords: foldable capsular vitreous body, FCVB, artificial vitreous substitutes, and artificial vitreous implants. Outcomes included indications of FCVB, anatomical success rates, postoperative intraocular pressure (IOP), best-corrected visual acuity (BCVA), and complications.

Results: A total of 17 studies that utilized FCVB up to May 2022 were included. FCVB was used intraocularly as a tamponade or extraocularly as a macular/scleral buckle for various retinal conditions including severe ocular trauma, simple and complex RD, silicone oil-dependent eyes, and highly myopic eyes with foveoschisis. FCVB was reported to be successfully implanted in the vitreous cavity of all patients. Final retinal reattachment rate ranged from 30 to 100%. Postoperative IOP improved or was maintained in most eyes, with low postoperative complication rates. Improvement in BCVA ranged from 0 to 100% of subjects.

Conclusion: Indications of FCVB implantation have recently widened to include multiple advanced ocular conditions such as complex RD, but also include simpler conditions as uncomplicated RD. FCVB implantation showed good visual and anatomical outcomes, few IOP fluctuations, and a good safety profile. Larger comparative studies are required to further evaluate FCVB implantation.

Keywords: Artificial vitreous; Foldable capsular vitreous body; Macular hole; Ocular Trauma; Retina; Retinal detachment; Vitreous implants.

Publication types

Systematic Review
Review

MeSH terms

Eye Injuries* / surgery
Humans
Intraocular Pressure
Orbital Implants
Retinal Detachment* / surgery
Vitrectomy / methods
Vitreoretinopathy, Proliferative* / surgery
Vitreous Body*