Possible psychedelic therapeutic mechanism

Science. 2023 Feb 17;379(6633):642-643. doi: 10.1126/science.adg2989. Epub 2023 Feb 16.

Authors

Evan M Hess¹, Todd D Gould^{1

2

3

4}

Affiliations

¹ Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
² Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.
³ Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
⁴ Baltimore Veterans Affairs Medical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.

Abstract

Psychedelics act on intracellular serotonin receptors that are not accessible by serotonin alone.

MeSH terms

Animals
Depression* / drug therapy
Hallucinogens* / pharmacology
Hallucinogens* / therapeutic use
Humans
N,N-Dimethyltryptamine* / pharmacology
N,N-Dimethyltryptamine* / therapeutic use
Receptor, Serotonin, 5-HT2A* / metabolism
Serotonin 5-HT2 Receptor Agonists* / pharmacology
Serotonin 5-HT2 Receptor Agonists* / therapeutic use
Serotonin* / metabolism
Serotonin* / pharmacology

Substances

Hallucinogens
N,N-Dimethyltryptamine
psilocin
Receptor, Serotonin, 5-HT2A
Serotonin
Serotonin 5-HT2 Receptor Agonists

Grants and funding

T32 MH067533/MH/NIMH NIH HHS/United States