American Society for Gastrointestinal Endoscopy guideline on management of post-liver transplant biliary strictures: summary and recommendations

Gastrointest Endosc. 2023 Apr;97(4):607-614. doi: 10.1016/j.gie.2022.10.007. Epub 2023 Feb 14.


This clinical practice guideline from the American Society for Gastrointestinal Endoscopy provides an evidence-based approach for strategies to manage biliary strictures in liver transplant recipients. This document was developed using the Grading of Recommendations Assessment, Development and Evaluation framework. The guideline addresses the role of ERCP versus percutaneous transhepatic biliary drainage and covered self-expandable metal stents (cSEMSs) versus multiple plastic stents for therapy of post-transplant strictures, use of MRCP for diagnosing post-transplant biliary strictures, and administration of antibiotics versus no antibiotics during ERCP. In patients with post-transplant biliary strictures, we suggest ERCP as the initial intervention and cSEMSs as the preferred stent for extrahepatic strictures. In patients with unclear diagnoses or intermediate probability of a stricture, we suggest MRCP as the diagnostic modality. We suggest that antibiotics should be administered during ERCP when biliary drainage cannot be ensured.

Publication types

  • Practice Guideline
  • Comment

MeSH terms

  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholestasis* / etiology
  • Cholestasis* / surgery
  • Constriction, Pathologic / etiology
  • Constriction, Pathologic / therapy
  • Endoscopy, Gastrointestinal
  • Humans
  • Liver Transplantation* / adverse effects
  • Stents
  • United States