Varicella-zoster virus (VZV) causes chickenpox when it first infects humans, and the virus may reactivate in adulthood and cause herpes zoster (HZ). Broad-spectrum antiviral drugs are one of the treatments for varicella and herpes zoster, but the emergence of drug resistance poses many challenges to this treatment and increases the burden of disease on patients. This paper discusses the resistance mechanisms, resistance sites and resistance detection methods of anti-VZV drugs in order to help further research on new anti-VZV targets, new drugs and monitoring of resistance to existing drugs.
水痘-带状疱疹病毒（VZV）初次感染人可引起水痘，病毒在成人时期可能再次激活并引起带状疱疹。广谱抗病毒药物是治疗水痘和带状疱疹的手段之一，但耐药现象的出现对该治疗方法带来了诸多挑战，同时也增加了患者的疾病负担。本文对抗VZV药物的耐药机制、耐药位点及耐药检测方法等方面进行论述，以期为进一步开展抗VZV新靶点、新药的研究及对现有药物的耐药性监测提供帮助。.