Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor KS-619-1

T Yasuzawa; M Yoshida; K Shirahata; H Sano

doi:10.7164/antibiotics.40.1111

Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor KS-619-1

J Antibiot (Tokyo). 1987 Aug;40(8):1111-4. doi: 10.7164/antibiotics.40.1111.

Authors

T Yasuzawa¹, M Yoshida, K Shirahata, H Sano

Affiliation

¹ Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.

PMID: 3680023
DOI: 10.7164/antibiotics.40.1111

Abstract

The structure of KS-619-1, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 8,13-dioxo-3-(2-oxopropyl)-5,6,8,13-tetrahydro-1,7,9,11- tetrahydroxybenz[a]naphtacene-2-carboxylic acid by spectral studies of KS-619-1 and its methyl derivative.

MeSH terms

Magnetic Resonance Spectroscopy
Mass Spectrometry
Phosphodiesterase Inhibitors*
Spectrum Analysis
Streptomyces / analysis

Substances

Phosphodiesterase Inhibitors