Targeting immunoregulation for cardiac regeneration

J Mol Cell Cardiol. 2023 Apr:177:1-8. doi: 10.1016/j.yjmcc.2023.02.003. Epub 2023 Feb 16.


Inducing endogenous cardiomyocyte proliferation and heart regeneration is a promising strategy to treat ischemic heart failure. The immune response has recently been considered critical in cardiac regeneration. Thus, targeting the immune response is a potent strategy to improve cardiac regeneration and repair after myocardial infarction. Here we reviewed the characteristics of the relationship between the postinjury immune response and heart regenerative capacity and summarized the latest studies focusing on inflammation and heart regeneration to identify potent targets of the immune response and strategies in the immune response to promote cardiac regeneration.

Keywords: Cell transplantation; Heart regeneration; Immune response; Inflammation; Interleukin-6; Myocardial injury.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Proliferation
  • Heart / physiology
  • Heart Failure*
  • Humans
  • Inflammation
  • Myocardial Infarction* / therapy
  • Myocytes, Cardiac / physiology