A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients

J Clin Psychiatry. 1987 Nov;48(11):442-4.

Abstract

Intravenous cocaine use is a major problem in methadone maintenance programs. In this pilot study of 16 cocaine-abusing methadone maintenance patients, 8 received desipramine and 8 received no medication other than methadone. During an 8-week open trial the desipramine patients reported significantly less cocaine craving and had less cocaine use than the other patients.

MeSH terms

  • Adult
  • African Americans
  • Antisocial Personality Disorder / psychology
  • Cocaine*
  • Desipramine / therapeutic use*
  • Female
  • Humans
  • Male
  • Methadone / therapeutic use*
  • Opioid-Related Disorders / complications
  • Opioid-Related Disorders / rehabilitation*
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / drug therapy*
  • Substance-Related Disorders / rehabilitation

Substances

  • Cocaine
  • Desipramine
  • Methadone