Cholesterol metabolism: Towards a therapeutic approach for multiple sclerosis

Yu-Han Gao; Xing Li

doi:10.1016/j.neuint.2023.105501

Cholesterol metabolism: Towards a therapeutic approach for multiple sclerosis

Neurochem Int. 2023 Mar:164:105501. doi: 10.1016/j.neuint.2023.105501. Epub 2023 Feb 15.

Authors

Yu-Han Gao¹, Xing Li²

Affiliations

¹ National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, 710119, China.
² National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, 710119, China. Electronic address: xingli_xian@126.com.

PMID: 36803679
DOI: 10.1016/j.neuint.2023.105501

Abstract

Growing evidence points to the importance of cholesterol in preserving brain homeostasis. Cholesterol makes up the main component of myelin in the brain, and myelin integrity is vital in demyelinating diseases such as multiple sclerosis. Because of the connection between myelin and cholesterol, the interest in cholesterol in the central nervous system increased during the last decade. In this review, we provide a detailed overview on brain cholesterol metabolism in multiple sclerosis and its role in promoting oligodendrocyte precursor cell differentiation and remyelination.

Keywords: Central nervous system; Cholesterol metabolism; Multiple sclerosis; Myelin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain
Cell Differentiation / physiology
Central Nervous System
Humans
Multiple Sclerosis* / drug therapy
Myelin Sheath / metabolism
Oligodendroglia / metabolism