Actin finally matures: uncovering machinery and impact

Thomas Arnesen; Henriette Aksnes

doi:10.1016/j.tibs.2023.02.002

Actin finally matures: uncovering machinery and impact

Trends Biochem Sci. 2023 May;48(5):414-416. doi: 10.1016/j.tibs.2023.02.002. Epub 2023 Feb 17.

Authors

Thomas Arnesen¹, Henriette Aksnes²

Affiliations

¹ Department of Biomedicine, University of Bergen, Bergen, Norway; Department of Biological Sciences, University of Bergen, Bergen, Norway; Department of Surgery, Haukeland University Hospital, Bergen, Norway. Electronic address: thomas.arnesen@uib.no.
² Department of Biomedicine, University of Bergen, Bergen, Norway. Electronic address: henriette.aksnes@uib.no.

PMID: 36804256
DOI: 10.1016/j.tibs.2023.02.002

Abstract

Actin, one of the most abundant proteins in nature and a key component of the cytoskeleton, undergoes a unique multistep N-terminal (Nt) maturation. In a recent report, Haahr et al. identified actin maturation protease (ACTMAP) as the dedicated actin aminopeptidase and showed that its absence is associated with abnormal muscle physiology.

Keywords: ACTMAP; NAA80; actin; aminopeptidase; cytoskeleton; protein N-terminal maturation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actin Cytoskeleton / metabolism
Actins* / metabolism
Cytoskeleton* / metabolism

Substances

Actins