Pancreatic Cancer: Changing Epidemiology and New Approaches to Risk Assessment, Early Detection, and Prevention

Gastroenterology. 2023 Apr;164(5):752-765. doi: 10.1053/j.gastro.2023.02.012. Epub 2023 Feb 18.


Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of preinvasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although screening for pancreatic cancer is currently not recommended for the general population, emerging evidence indicates that pancreatic surveillance can improve outcomes for individuals in certain high-risk groups. Changes in the epidemiology of pancreatic cancer, experience from pancreatic surveillance, and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic cancer risk assessment, early detection, and prevention.

Keywords: Genetic Susceptibility; Pancreatic Cancer; Surveillance.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Early Detection of Cancer* / methods
  • Humans
  • Pancreas
  • Pancreatic Neoplasms* / diagnosis
  • Pancreatic Neoplasms* / epidemiology
  • Pancreatic Neoplasms* / prevention & control
  • Risk Assessment
  • Risk Factors