A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410

Zhijun Yang; Kai Wu; Wangli Ji; Yu Yin; Xiaojing Wang; Lei Shao; Mei Ge; Yixin Xu

doi:10.1038/s41429-022-00586-8

A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410

J Antibiot (Tokyo). 2023 Apr;76(4):239-243. doi: 10.1038/s41429-022-00586-8. Epub 2023 Feb 17.

Authors

Zhijun Yang^{1

2}, Kai Wu^{1

2}, Wangli Ji¹, Yu Yin³, Xiaojing Wang², Lei Shao², Mei Ge⁴, Yixin Xu⁵

Affiliations

¹ School of Pharmacy, Shanghai University of Medine&Health Sciences, Shanghai, China.
² Microbial Pharmacology Laboratory, Shanghai University of Medine & Health Sciences, Shanghai, China.
³ Shanghai Laiyi Center for Biopharmaceutical R&D, Shanghai, China.
⁴ Shanghai Laiyi Center for Biopharmaceutical R&D, Shanghai, China. gemei@yeah.net.
⁵ School of Pharmacy, Shanghai University of Medine&Health Sciences, Shanghai, China. Xuyx@sumhs.edu.cn.

PMID: 36806196
DOI: 10.1038/s41429-022-00586-8

Abstract

A novel 3,4-dihydroisocoumarin glycoside (1) was obtained from the culture of endophytic fungal Xylaria CGMCC No.5410 from the leaves of Selaginella moellendorffii Hieron, together with five known compounds (2-6). Their structures elucidations were conducted by HRESIMS, NMR and IR spectroscopic analysis. All the isolated compounds were evaluated for their antimicrobial, anti-tumor, and anti-HIV-1 activities. Compound 1 only displayed weak antimicrobial activity against micrococcus luteus. The other known compounds showed different antimicrobial, anti-tumor, or anti-HIV-1 activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents*
Magnetic Resonance Spectroscopy
Molecular Structure
Xylariales* / chemistry

Substances

3,4-dihydroisocoumarin
Anti-Infective Agents