Treatment of gangrenous digit-threatening paraneoplastic acrocyanosis with vasodilator therapy

BMJ Case Rep. 2023 Feb 21;16(2):e251417. doi: 10.1136/bcr-2022-251417.


A man in his 70s, with a recent diagnosis of transitional cell carcinoma of the bladder, reported a 2-month history of discolouration, pain and paraesthesia affecting his fingers. Clinical assessment noted peripheral acrocyanosis with areas of digital ulceration and gangrene. Following further work-up to evaluate potential causes, he was diagnosed with paraneoplastic acrocyanosis. He proceeded to undergo robotic cystoprostatectomy and received adjuvant chemotherapy for the management of his cancer. In parallel to the chemotherapy, vasodilatory therapy was administered as two courses of intravenous synthetic prostacyclin analogue iloprost along with sildenafil. This resulted in a significant improvement in digital pain and gangrene with healing of ulceration.

Keywords: Oncology; Rheumatology.

Publication types

  • Case Reports

MeSH terms

  • Epoprostenol
  • Gangrene* / etiology
  • Humans
  • Iloprost
  • Male
  • Sildenafil Citrate
  • Vasodilator Agents* / therapeutic use


  • Vasodilator Agents
  • Iloprost
  • Epoprostenol
  • Sildenafil Citrate