The Goldilocks Oxygen Principle: not too little and not too much

Will R Flanigan; Isha H Jain

doi:10.1038/s44161-022-00178-7

The Goldilocks Oxygen Principle: not too little and not too much

Nat Cardiovasc Res. 2022 Dec;1(12):1101-1103. doi: 10.1038/s44161-022-00178-7. Epub 2022 Dec 12.

Authors

Will R Flanigan^{1

2}, Isha H Jain^{1

3

4}

Affiliations

¹ Gladstone Institutes, San Francisco, CA, USA.
² UCSF-UC Berkeley Joint PhD Program in Bioengineering, Berkeley, CA, USA.
³ Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
⁴ Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.

Abstract

Nature has evolved creative ways to maintain oxygen homeostasis, but what happens when these adaptations are insufficient? Here we discuss biochemical failure points across the oxygen spectrum from 'too little' to 'too much' oxygen and their potential contributions to cardiovascular disease.

Abstract

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